Next-generation Intersample Correlation Emended Renew(NICER)
is a statistical test for correcting for expression heterogeneity
inherent in expression dataset due to confounding from unmodeled
factors. NICER estimates inter-sample correlation structure using
only the genes with confounding effects and incorporates it as
signatures of the systematic confounding effects to correct for
it. (Click the bold text if you want to use the program manually.)